THAWING PRIOR TO USE

• Thaw vial(s) of Pfizer-BioNTech COVID-19 Vaccine, Bivalent before use either by:
   

  • Allowing vial(s) to thaw in the refrigerator (2°C to 8°C)

    • A carton of 10 single dose vials may take up to 2 hours to thaw

    • A carton of 10 multiple dose vials may take up to 6 hours to thaw

  • Allowing vial(s) to sit at room temperature (up to 25°C) for 30 minutes

• Thawed vials can be stored in the refrigerator (2°C to 8°C) for up to 10 weeks prior to use 

• Thawed vials may be stored at room temperature (up to 25°C) for up to 12 hours prior to use

PREPARATION OF INDIVIDUAL 0.3 mL DOSES

Single Dose Vial

• Withdraw a single 0.3 mL dose of the Pfizer-BioNTech COVID-19 Vaccine, Bivalent

• Administer immediately

• Discard vial and any excess volume

Multiple Dose Vial 

• Multiple dose vials contain 6 doses of 0.3 mL each

• Withdraw 0.3 mL of the Pfizer-BioNTech COVID-19 Vaccine, Bivalent preferentially using low dead volume syringes and/or needles. If standard syringes and needles are used, there may not be sufficient volume to extract 6 doses from a single vial

• Administer immediately

• If the amount of vaccine remaining in a multiple dose vial cannot provide a full dose of 0.3 mL, discard the vial and any excess volume