Pfizer-BioNTech COVID-19 Vaccine Vial with Orange Cap and Label with Orange Border – VIAL VERIFICATION

• Verify that the vial of Pfizer‑BioNTech COVID‑19 Vaccine has an orange plastic cap and a label with an orange border and states “Age 5y to < 12y”

THAWING PRIOR TO DILUTION
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Thaw vial(s) of the vaccine before use either by:

• Allowing vial(s) to thaw in the refrigerator (2°C to 8°C). A carton of 10 vials may take up to 4 hours to thaw, and thawed vials can be stored in the refrigerator for up to 10 weeks
  
  
• Allowing vial(s) to sit at room temperature (up to 25°C) for 30 minutes
  
  
• Vials may be stored at room temperature (up to 25°C) for up to 12 hours prior to use

• Before dilution, mix by inverting vaccine vial gently 10 times
    
• Do not shake
  
  
• Inspect the liquid in the vial prior to dilution. The liquid is a white to off-white suspension and may contain opaque amorphous particles
  
  
• Do not use if liquid is discolored or if other particles are observed

DILUTION

• Obtain sterile 0.9% Sodium Chloride Injection, USP. Use only this as the diluent
  
  
• Using aseptic technique, withdraw 1.3 mL of diluent into a transfer syringe (21‑gauge or narrower needle)
  
  
• Cleanse the vaccine vial stopper with a single‑use antiseptic swab
  
  
• Add 1.3 mL of sterile 0.9% Sodium Chloride Injection, USP into the vaccine vial

• Equalize vial pressure before removing the needle from the vial by withdrawing 1.3 mL air into the empty diluent syringe

• Gently invert the vial containing the vaccine 10 times to mix 
  
  
• Do not shake
  
  
• Inspect the vaccine in the vial
  
  
• The vaccine will be a white to off-white suspension. Do not use if vaccine is discolored or contains particulate matter 

• Record the date and time of dilution on the vial label 
   
• Store between 2°C to 25°C
   
• Discard any unused vaccine 12 hours after dilution

WITHDRAWAL OF INDIVIDUAL 0.2 mL DOSES

• Using aseptic technique, cleanse the vial stopper with a single-use antiseptic swab, and withdraw 0.2 mL of the Pfizer-BioNTech COVID-19 Vaccine preferentially using a low dead-volume syringe and/or needle
  
  
• Each dose must contain 0.2 mL of vaccine
  
  
• If the amount of vaccine remaining in the vial cannot provide a full dose of 0.2 mL, discard the vial and any excess volume
  
  
• Administer immediately